Quantum dot-based electrochemical sensors for early detection and monitoring of blood cancer

  • Md. Rakibul Islam Department of Chemical Engineering, Z. H. Sikder University of Science and Technology (ZHSUST), Shariatpur 8024, Bangladesh
  • Mashrufa Akther Department of Chemical Engineering, Z. H. Sikder University of Science and Technology (ZHSUST), Shariatpur 8024, Bangladesh
  • Md. Sharif Mia Department of Chemical Engineering, Z. H. Sikder University of Science and Technology (ZHSUST), Shariatpur 8024, Bangladesh
  • Sarna Akter Department of Chemical Engineering, Z. H. Sikder University of Science and Technology (ZHSUST), Shariatpur 8024, Bangladesh
  • Md. Sagor Ahammed Department of Chemical Engineering, Z. H. Sikder University of Science and Technology (ZHSUST), Shariatpur 8024, Bangladesh
  • Md. Rahim Uddin Department of Chemical Engineering, Z. H. Sikder University of Science and Technology (ZHSUST), Shariatpur 8024, Bangladesh; Department of Chemical Engineering, College of Environmental Science and Forestry, State University of New York, Syracuse, NY 13210, USA
  • Md. Mahmud Alam Department of Chemical Engineering, Z. H. Sikder University of Science and Technology (ZHSUST), Shariatpur 8024, Bangladesh
Keywords: quantum dots; electrochemical sensors; blood cancer; leukemia; lymphoma; cancer biomarkers; circulating tumor cells (CTCs); minimal residual disease (MRD)
Article ID: 2015

Abstract

Recent advancements in quantum dot (QD)-based electrochemical sensors have shown significant promise for the early detection and monitoring of blood cancers, such as leukemia and lymphoma. QDs, with their unique optical properties, high surface area, and tunable fluorescence, offer highly sensitive and specific detection of cancer biomarkers, enabling rapid, real-time diagnostics. These sensors are capable of multiplexed detection, allowing for the simultaneous identification of multiple biomarkers or circulating tumor cells (CTCs), crucial for early diagnosis and monitoring minimal residual disease (MRD). Despite their potential, challenges remain, including concerns over biocompatibility, toxicity, and the need for regulatory approval. Future research is focused on addressing these issues by developing non-toxic, biocompatible QDs, optimizing sensor performance, and integrating these technologies into point-of-care devices. Additionally, the combination of electrochemical and optical sensing techniques, along with advancements in surface modification and signal enhancement, holds promise for further improving the sensitivity, reliability, and clinical applicability of QD-based sensors. As research progresses, QD-based electrochemical sensors are poised to become a powerful tool for non-invasive, early-stage blood cancer detection and personalized treatment monitoring.

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Published
2025-05-28
How to Cite
Islam, M. R., Akther, M., Mia, M. S., Akter, S., Ahammed, M. S., Uddin, M. R., & Alam, M. M. (2025). Quantum dot-based electrochemical sensors for early detection and monitoring of blood cancer. Quantum Nexus, 1(1), 2015. Retrieved from https://sin-chn.com/index.php/QN/article/view/2015
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