Mechanical characterization of intracellular drug transport based on optimization of chemical engineering principles
Abstract
At present, the measurement of cellular mechanical properties is divided into contact and non-contact, combined with the actual situation of the research in this paper, according to which the optical tweezers measurement technology in the non-contact type is adopted. Taking the measured value of cellular mechanical properties as the entry point of this research, the optimization method commonly used in chemical engineering principles was adopted, and the optimization model based on the separation of viscoelasticity parameters was set up by constantly changing the viscoelasticity parameters of intracellular transport of drugs and setting up certain criteria to optimize and obtain the viscoelasticity parameters that best represent the mechanical properties of intracellular transport of drug cells. The model was used to experimentally analyze the mechanical properties of intracellular drug transport. The deformation of drug cells when reaching the predetermined elastic force was small when transported with the optimized transport speed curve of parameter , and the transport speed was the largest, while the deformation obtained with the transport speed curve of parameter was between the two, indicating that the optimized speed curve of viscoelasticity parameter can effectively reduce the mechanical damage of the drug cells in the process of transport.
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