Exploration of molecular mechanics mechanism of muscle contraction in musical instrument performance
Abstract
This study focuses on the molecular biomechanical mechanisms of muscle contraction during musical instrument performance. Through systematic investigation of 120 musicians from different instrument groups (30 each in string, keyboard, wind, and percussion sections), using fluorescence resonance energy transfer, single-molecule tracking techniques, and high-precision electromyography systems, we analyzed molecular motor movement characteristics, calcium signal dynamics, and cross-bridge cycling mechanisms during performance. The research revealed significant differences in molecular mechanical parameters among different types of instrumentalists: the string group demonstrated the highest cross-bridge cycling rate (458 ± 35 s−1) and fastest calcium signal response (τon = 1.2 ± 0.1 ms); the keyboard group showed the highest ATPase activity (42.3 ± 3.6 μmol/min/g) and the highest proportion of strongly bound cross-bridges (35.8 ± 3.2%). Performance proficiency significantly correlated with molecular mechanical parameters (r = 0.856, P < 0.01), indicating that molecular-level adaptive changes are fundamental to skill improvement. Based on these findings, we propose molecular biological strategies for optimizing practice methods, including intermittent training patterns based on ATP supply characteristics, progressive loading schemes considering calcium signal adaptation periods, and preventive measures targeting molecular motor fatigue patterns. The results provide new perspectives for understanding the biomechanical mechanisms of musical instrument performance while offering theoretical foundations for improving performance levels and preventing occupational injuries.
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