A biomechanics research on drug therapy in the rehabilitation of sports training injuries

  • Lulu Yang Sports College, Shanxi Vocational University of Engineering Science and Technology, Taiyuan 030619, China
  • Yu Dong Basic department, Wuhan Donghu University, Wuhan 430212, China
Keywords: athletic training; sports injury; drug therapy; vas simulation scoring technique; cytoscape analysis technique
Ariticle ID: 215

Abstract

In the process of sports training and competition, if sports injury occurs, it not only has a serious impact on the physical and psychological of athletes, but also has a negative impact on the overall training and competition. During the competition, if effective treatment is not obtained, it can have an irreversible impact on athletes’ future participation in sports. Nowadays, many athletes lack knowledge on the prevention and treatment of sports injuries during physical exercise. Therefore, it is urgent to conduct research and analysis on the treatment methods for training injury rehabilitation. In this paper, the visual analogue scale (VAS) and cell landscape analysis technology were used to analyze and compare the therapeutic effects of platelet rich plasma (PRP) injection technology, diclofenac, indomethacin, Qili San and placebo tablets. Focusing on how these drugs promote rehabilitation by affecting mechanical parameters and tissue mechanical properties, it is concluded that PRP injection technique, diclofenac and indomethacin improve the treatment effect of pain after rehabilitation of sports injuries. The number of people who completely recovered with Indomethacin was 4 and that with placebo was 2. The results show that these drugs significantly improve the mechanical properties of the tissue and contribute to the rehabilitation process. This study has further explored the drug treatment of sports injury, explored several drug treatment mechanisms and efficacy and has guiding significance for subsequent drug treatment of sports injury.

References

Goddard K, Roberts CM, Byron-Daniel J, et al. Psychological factors involved in adherence to sport injury rehabilitation: a systematic review. International Review of Sport and Exercise Psychology. 2020; 14(1): 51-73. doi: 10.1080/1750984x.2020.1744179

Gennarelli SM, Brown SM, Mulcahey MK. Psychosocial interventions help facilitate recovery following musculoskeletal sports injuries: a systematic review. The Physician and Sportsmedicine. 2020; 48(4): 370-377. doi: 10.1080/00913847.2020.1744486

Xu S, Zeng L. Rehabilitation Path of Knee Ligament Proprioception Loss Caused by Sports Injury. Clinical research. 2020; 61(3): 1258-1267.

Malmgaard-Clausen NM, Jørgensen OH, Høffner R, et al. No Additive Clinical or Physiological Effects of Short-term Anti-inflammatory Treatment to Physical Rehabilitation in the Early Phase of Human Achilles Tendinopathy: A Randomized Controlled Trial. The American Journal of Sports Medicine. 2021; 49(7): 1711-1720. doi: 10.1177/0363546521991903

Wiffen PJ, Xia J. Systematic review of topical diclofenac for the treatment of acute and chronic musculoskeletal pain. Current Medical Research and Opinion. 2020; 36(4): 637-650. doi: 10.1080/03007995.2020.1716703

Haider MN, Herget L, Zafonte RD, et al. Rehabilitation of Sport-Related Concussion. Clinics in Sports Medicine. 2021; 40(1): 93-109. doi: 10.1016/j.csm.2020.08.003

Sánchez Díaz M, Martín-Castellanos A, Fernández-Elías VE, et al. Effects of Polyphenol Consumption on Recovery in Team Sport Athletes of Both Sexes: A Systematic Review. Nutrients. 2022; 14(19): 4085. doi: 10.3390/nu14194085

Gentile P, Garcovich S. Systematic Review—The Potential Implications of Different Platelet-Rich Plasma (PRP) Concentrations in Regenerative Medicine for Tissue Repair. International Journal of Molecular Sciences. 2020; 21(16): 5702. doi: 10.3390/ijms21165702

Huang H, Luo M, Liang H, et al. Meta-analysis Comparing Celecoxib with Diclofenac Sodium in Patients with Knee Osteoarthritis. Pain Medicine. 2020; 22(2): 352-362. doi: 10.1093/pm/pnaa230

Fogel EL, Lehman GA, Tarnasky PC, et al. Rectal indometacin dose escalation for prevention of pancreatitis after endoscopic retrograde cholangiopancreatography in high-risk patients: a double-blind, randomised controlled trial. The Lancet Gastroenterology & Hepatology.2020; 5(2): 132-141. doi:10.1016/S2468-1253(19)30337-1

Alves R, Grimalt R. A Review of Platelet-Rich Plasma: History, Biology, Mechanism of Action, and Classification. Skin Appendage Disorders. 2017; 4(1): 18-24. doi: 10.1159/000477353

Everts PA, van Erp A, DeSimone A, et al. Platelet Rich Plasma in Orthopedic Surgical Medicine. Platelets. 2021; 32(2): 163-174. doi: 10.1080/09537104.2020.1869717

Sarı S, Aydın ON, Turan Y, et al. Which one is more effective for the clinical treatment of chronic pain in knee osteoarthritis: radiofrequency neurotomy of the genicular nerves or intra‐articular injection? International Journal of Rheumatic Diseases. 2016; 21(10): 1772-1778. doi: 10.1111/1756-185x.12925

Chang NJ, Erdenekhuyag Y, Chou PH, et al. Therapeutic Effects of the Addition of Platelet-Rich Plasma to Bioimplants and Early Rehabilitation Exercise on Articular Cartilage Repair. The American Journal of Sports Medicine. 2018; 46(9): 2232-2241. doi: 10.1177/0363546518780955

Lundberg TR, Howatson G. Analgesic and anti‐inflammatory drugs in sports: Implications for exercise performance and training adaptations. Scandinavian Journal of Medicine & Science in Sports. 2018; 28(11): 2252-2262. doi: 10.1111/sms.13275

Jiang M, Li F,Li F, et al. Experimental study on the anti-inflammatory effect of qilisan with and without cinnabar. Shandong Chemical Industry 2018; 47(4): 25-26.

Liu Z, Xie L, Jin Y,et al. Quantitative microscopic study of saffron in Qilisan. Journal of Pharmaceutical Research. 2020; 39(7): 385-387.

Yao X, Zhang X, Ma S, et al. Study on the Mechanism of Sanqi in the Treatment of Disseminated Intravascular Coagulation-Based on Network Pharmacology and Molecular Docking Technology. Letters in Drug Design & Discovery. 2023; 20(7): 881-893. doi: 10.2174/1570180819666220512110520

Shan S. A review of the modalities and application of Chinese medicine in the treatment of delayed fracture healing. Chinese Journal of Convalescent Medicine. 2018; 27(3): 252-253.

Published
2024-09-24
How to Cite
Yang, L., & Dong, Y. (2024). A biomechanics research on drug therapy in the rehabilitation of sports training injuries . Molecular & Cellular Biomechanics, 21(1), 215. https://doi.org/10.62617/mcb.v21i1.215
Section
Article