A biomechanical study of lower limb distal joint asymmetry during running using bionic shoe
Abstract
Lower limb asymmetry associated with running can reveal relevant information about sports injuries. Although the biomechanical study of bionic shoes (BS) has developed well, the understanding of how BS affects lower limb asymmetry during running is limited. The objective of this study was to compare the asymmetry between the dominant and non-dominant limbs of the participants under NS and BS conditions. The research involved the enrollment of 26 male individuals who were actively involved in running (age: 27.30 ± 3.70 years old, height: 1.72 ± 0.03 m, body mass: 66.70 ± 8.20 kg, body mass index: 22.40 ± 2.30 kg/m2). Participants were required to run at a speed of 12 km/h wearing BS and neutral shoes (NS) respectively. Lower limb asymmetry during running was analyzed by investigating biomechanical parameters such as range of motion, peak angular velocity, peak moment, power, and work of the bilateral knee and ankle during the running stance phase. A two-way analysis of variance (ANOVA) was employed to determine the differences in joint biomechanics (p < 0.05) using a factorial design. Additionally, paired sample t-tests were conducted to determine the differences in symmetry angles (SA) for each of the analyzed biomechanical parameters. Compared to NS, BS optimized the asymmetry in knee (p = 0.015) and ankle (p < 0.001) angles between the dominant and non-dominant lower limbs during the push-off phase, and the BS optimized the asymmetry in knee extension work (p = 0.049) between the dominant and non-dominant lower limbs in the stance phase of running. However, it also resulted in increases in peak angular velocity (p = 0.049), power (p = 0.018), and work (p = 0.035) during dominant lower limb ankle dorsiflexion. Without considering the effects of the shoes, there would be differences in peak extension moment (p = 0.05) and flexion work (p = 0.005) of the bilateral knee during running, as well as differences in peak dorsiflexion angular velocities (p = 0.001) and plantarflexion work (p = 0.039) of the bilateral ankle. These differences can also affect the peak angular velocity in dorsiflexion and the work in plantarflexion. The findings suggest that BS improved asymmetry of the knee and ankle and demonstrated bilateral lower limb asymmetry during running. These findings provide insights into understanding sports injuries such as anterior cruciate ligament injuries of the knee and information relating to ankle sprains. The findings also offer beneficial information in the design of BS.
References
1. Messier SP, Martin DF, Mihalko SL, Ip E, DeVita P, Cannon DW, Love M, Beringer D, Saldana S, Fellin RE. (2018). A 2-year prospective cohort study of overuse running injuries: the runners and injury longitudinal study (TRAILS). The American journal of sports medicine, 46(9):2211-2221.
2. Ramskov D, Rasmussen S, Sørensen H, Parner ET, Lind M, Nielsen R. (2022). Interactions Between Running Volume and Running Pace and Injury Occurrence in Recreational Runners: A Secondary Analysis. Journal of Athletic Training, 57(6):557-563.
3. Wayner RA, Robinson R, Simon JE. (2023). Gait asymmetry and running-related injury in female collegiate cross-country runners. Physical Therapy in Sport, 59:1-6.
4. Stiffler-Joachim MR, Lukes DH, Kliethermes SA, Heiderscheit BC. (2021). Lower Extremity Kinematic and Kinetic Asymmetries during Running. Medicine and Science in Sports and Exercise, 53(5):945-950.
5. Gao Z, Zhao L, Fekete G, Katona G, Baker JS, Gu Y. (2022). Continuous time series analysis on the effects of induced running fatigue on leg symmetry using kinematics and kinetic variables: Implications for knee joint injury during a countermovement jump. Frontiers in Physiology, 13:877394.
6. Afonso J, Peña J, Sá M, Virgile A, García-de-Alcaraz A, Bishop C. (2022). Why sports should embrace bilateral asymmetry: A narrative review. Symmetry, 14(10):1993.
7. Radzak KN, Putnam AM, Tamura K, Hetzler RK, Stickley CD. (2017). Asymmetry between lower limbs during rested and fatigued state running gait in healthy individuals. Gait & posture, 51:268-274.
8. Helme M, Tee J, Emmonds S, Low C. (2021). Does lower-limb asymmetry increase injury risk in sport? A systematic review. Physical Therapy in Sport, 49:204-213.
9. Dai B, Butler R, Garrett W, Queen R. (2014). Using ground reaction force to predict knee kinetic asymmetry following anterior cruciate ligament reconstruction. Scandinavian journal of medicine & science in sports, 24(6):974-981.
10. Niu W, Wang Y, He Y, Fan Y, Zhao Q. (2011). Kinematics, kinetics, and electromyogram of ankle during drop landing: a comparison between dominant and non-dominant limb. Human movement science, 30(3):614-623.
11. Ito N, Capin JJ, Arhos EK, Khandha A, Buchanan TS, Snyder‐Mackler L. (2021). Sex and mechanism of injury influence knee joint loading symmetry during gait 6 months after ACLR. Journal of Orthopaedic Research®, 39(5):1123-1132.
12. Perraton LG, Hall M, Clark RA, Crossley KM, Pua Y-H, Whitehead TS, Morris HG, Culvenor AG, Bryant AL. (2018). Poor knee function after ACL reconstruction is associated with attenuated landing force and knee flexion moment during running. Knee Surgery, Sports Traumatology, Arthroscopy, 26:391-398.
13. Yalfani A, Raeisi Z. (2022). Bilateral symmetry of vertical time to stabilization in postural sway after double-leg landing in elite athletes with unilateral chronic ankle sprain. Journal of Foot and Ankle Research, 15(1):1-9.
14. Beck ON, Azua EN, Grabowski AM. (2018). Step time asymmetry increases metabolic energy expenditure during running. European journal of applied physiology, 118:2147-2154.
15. Girard O, Morin J-B, Ryu J, Read P, Townsend N. (2019). Running velocity does not influence lower limb mechanical asymmetry. Frontiers in Sports and Active Living, 1:36.
16. Gilgen-Ammann R, Taube W, Wyss T. (2017). Gait asymmetry during 400-to 1000-m high-intensity track running in relation to injury history. International Journal of Sports Physiology and Performance, 12(S2)-S2-157-S152-160.
17. Nigg BM, Emery C, Hiemstra LA. (2006). Unstable shoe construction and reduction of pain in osteoarthritis patients. Medicine & Science in Sports & Exercise, 38(10):1701-1708.
18. Sousa AS, Tavares JMR. (2012). Effect of gait speed on muscle activity patterns and magnitude during stance. Motor Control, 16(4):480-492.
19. Becker J, Borgia B. (2020). Kinematics and muscle activity when running in partial minimalist, traditional, and maximalist shoes. Journal of Electromyography and Kinesiology, 50:102379.
20. Lieberman DE, Venkadesan M, Werbel WA, Daoud AI, D’andrea S, Davis IS, Mang’Eni RO, Pitsiladis Y. (2010). Foot strike patterns and collision forces in habitually barefoot versus shod runners. Nature, 463(7280):531-535.
21. Angeleska E, Sidorenko S. (2021). Bio-inspired back support system for backpacks. FME Transactions, 49(2):327-334.
22. Zhang R, Zhao L, Kong Q, Yu G, Yu H, Li J, Tai W-H. (2022). The Bionic High-Cushioning Midsole of Shoes Inspired by Functional Characteristics of Ostrich Foot. Bioengineering, 10(1):1.
23. Xu D, Zhou H, Jiang X, Li S, Zhang Q, Baker JS, Gu Y. (2022). New insights for the design of bionic robots: Adaptive motion adjustment strategies during feline landings. Frontiers in Veterinary Science, 9.
24. Spurrier S, Allen T, Grant RA. (2023). Investigating Foot Morphology in Rock Climbing Mammals: Inspiration for Biomimetic Climbing Shoes. Biomimetics, 8(1):8.
25. Khoury-Mireb M, Solomonow-Avnon D, Rozen N, Wolf A. (2019). The effect of unstable shoe designs on the variability of gait measures. Gait & Posture, 69:60-65.
26. Horsak B, Heller M, Baca A. (2015). Muscle co-contraction around the knee when walking with unstable shoes. Journal of electromyography and kinesiology, 25(1):175-181.
27. Stöggl T, Haudum A, Birklbauer J, Murrer M, Müller E. (2010). Short and long term adaptation of variability during walking using unstable (Mbt) shoes. Clinical Biomechanics, 25(8):816-822.
28. Zhang M, Cui J, Liu H. (2022). Effect of Flat Running Shoes on Hip Kinematics in Male Recreational Runners. International Journal of Environmental Research and Public Health, 19(24):16473.
29. Alentorn-Geli E, Samuelsson K, Musahl V, Green CL, Bhandari M, Karlsson J. (2017). The association of recreational and competitive running with hip and knee osteoarthritis: a systematic review and meta-analysis. journal of orthopaedic & sports physical therapy, 47(6):373-390.
30. Chen H, Shao E, Sun D, Xuan R, Baker JS, Gu Y. (2022). Effects of footwear with different longitudinal bending stiffness on biomechanical characteristics and muscular mechanics of lower limbs in adolescent runners. Frontiers in Physiology, 13:907016.
31. Sinclair J, Selfe J. (2015). Sex differences in knee loading in recreational runners. Journal of biomechanics, 48(10):2171-2175.
32. Zhou H, Xu D, Quan W, Liang M, Ugbolue UC, Baker JS, Gu Y. (2021). A pilot study of muscle force between normal shoes and bionic shoes during men walking and running stance phase using opensim. Actuators, MDPI, 10(10), 274.
33. Zifchock RA, Davis I, Higginson J, Royer T. (2008). The symmetry angle: a novel, robust method of quantifying asymmetry. Gait & posture, 27(4):622-627.
34. Mei Q, Gu Y, Xiang L, Baker JS, Fernandez J. (2019). Foot pronation contributes to altered lower extremity loading after long distance running. Frontiers in Physiology, 10:573.
35. Jiang X, Chen H, Sun D, Baker JS, Gu Y. (2021). Running speed does not influence the asymmetry of kinematic variables of the lower limb joints in novice runners. Acta Bioeng Biomech, 23(1):69-81.
36. Liu Q, Chen H, Song Y, Alla N, Fekete G, Li J, Gu Y. (2022). Running Velocity and Longitudinal Bending Stiffness Influence the Asymmetry of Kinematic Variables of the Lower Limb Joints. Bioengineering, 9(11):607.
37. Nigg B, Federolf PA, von Tscharner V, Nigg S. (2012). Unstable shoes: functional concepts and scientific evidence. Footwear Science, 4(2):73-82.
38. Sousa AS, Macedo R, Santos R, Tavares JMR. (2013). Influence of wearing an unstable shoe construction on compensatory control of posture. Human Movement Science, 32(6):1353-1364.
39. Bonacci J, Saunders PU, Hicks A, Rantalainen T, Vicenzino BGT, Spratford W. (2013). Running in a minimalist and lightweight shoe is not the same as running barefoot: a biomechanical study. British journal of sports medicine, 47(6):387-392.
40. Dellagrana RA, Diefenthaeler F, Carpes FP, Hernandez SG, de Campos W. (2015). Evidence for isokinetic knee torque asymmetries in male long distance‐trained runners. International journal of sports physical therapy, 10(4):514.
41. Yekini A, Grace JM, (2023). Effects of Eccentric Exercise on Work-Related Performance and Physical Activity Levels in Rheumatoid Arthritis Patients. Physical Activity and Health, 7,:293–302.
42. Gu Y, Lu Y, Mei Q, Li J, Ren J. (2014). Effects of different unstable sole construction on kinematics and muscle activity of lower limb. Human movement science, 36:46-57.
43. Jiang X, Yang X, Zhou H, Baker JS, Gu Y. (2021). Prolonged running using bionic footwear influences lower limb biomechanics. Healthcare, MDPI, 9(2), 236.
Copyright (c) 2025 Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright on all articles published in this journal is retained by the author(s), while the author(s) grant the publisher as the original publisher to publish the article.
Articles published in this journal are licensed under a Creative Commons Attribution 4.0 International, which means they can be shared, adapted and distributed provided that the original published version is cited.