Drug-carrying properties and targeted delivery of biomimetic nanoparticles delivering wild baicalin and Adriamycin
Abstract
The extensive application of biomaterials and nanotechnology in biomedical technology can enhance the drug-carrying performance and targeted therapeutic ability of drug nanoparticles. In the article, biomimetic nanoparticles of wild baicalin and adriamycin were prepared based on conventional means, and the drug release performance of SCU/DOX was analysed using drug release kinetics and the inhibitory effect of SCU/DOX nanoparticles on tumour cells. The nanoparticles were produced through nanotechnology after the main experimental scheme was prepared for the preparation of the basic medicine. At the same time, the study combines the biological electrical signal to obtain the value of the relevant measurement index. When the SCU/DOX nanodrug concentration was elevated from 10 μM to 16010 μM, the viability of mouse tumour cells was reduced from 82.54% to about 47.69%. This shows that nanoparticles can effectively deliver drugs. After the use of SCU drug alone and SCU/DOX nanoparticles, the IC50 values of both were 59.42 μM and 8.75 μM, respectively, with a reversal of resistance multiplier of 6.79-fold. Tumour cell treatment with SCU/DOX nanoparticles reduced the tumour volume from 15.1*102mm3 to 6.05*102mm3 and tumour weight by 64.14% in mice. The cumulative drug release from SCU/DOX nanoparticles was 11.18% at 2h, and higher than that of the esterase-free condition after 20h (17.61%). The data of the cumulative release of the drug show that the release of biomimetic nanoparticles can actually target the target. The unique quality of nanomaterials can allow drugs to release drugs in the set target environment. On the basis of this study, if clinical trials can also achieve good results, they are expected to be applied in practice. The preparation of baicalin and adriamycin mimetic nanoparticles based on the drug delivery system can enhance the drug-carrying property and target delivery effect of the drug, which can provide a reliable technical support to enhance the therapeutic effect of the disease.
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