Association between polychlorinated biphenyls and periodontitis: Results from the NHANES 1999–2002
Abstract
Background: Periodontitis is prevalent among large population, which may induce in bone destruction, attachment loss and finally tooth loss. Polychlorinated biphenyl (PCB) is one of the persistent organic pollutants (POPs), which are endocrine disruptors may destroy the integrity of tissue through possible mechanisms. Recent research has suggested that PCBs can accumulate in adipose tissue and increase the risk of periodontal disease by disturbing the immune system. This cross-sectional study investigated the relationship between PCBs and periodontitis in the general population. Methods: In general, cross-sectional associations of PCBs with the prevalence of periodontal disease were investigated in 263 patients in the National Health and Nutrition Examination Survey 1999–2002. Multivariate and stratified analysis was used to measure the association between PCBs and periodontitis. Results: From 1999 to 2002, the total number of patients in the National Health and Nutrition Examination Survey (NHANES) database was 21,004, and 3082 patients were finally enrolled after removing the patients who had not been tested for PCBs. Fully adjusted multivariable logistic regressions was performed on PCB lipid adjustments, and the results suggested a positive correlation between PCB180 and periodontitis. Subgroup analysis showed a negative correlation between PCB180 lipid adjustment and periodontitis in patients aged < 20 years (P for interaction = 0.002). Conclusion: PCB180 is positively correlated with periodontitis of the age over than 20s. However, further studies need to be investigated that whether PCBs affected biomechanical pathways to destroy tissue integrity. This study provides new insights for the prevention of periodontitis from the perspective of environmental exposure.
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