Causal link between physical activity and juvenile idiopathic arthritis through inflammatory cytokines
Abstract
Objective: This study aims to investigate the causal relationship between physical activity and Juvenile Idiopathic Arthritis (JIA) using Mendelian Randomisation (MR), with a particular focus on the regulatory mechanisms of inflammatory factors SCGF-beta, IP-10, and IFN-lambda 2. This abstract seeks to elucidate these biological relationships and provide a foundation for future therapeutic strategies. Methods: We employed Mendelian randomisation techniques to assess the impact of physical exercise on SCGF-beta, IP-10, and IFN-lambda 2. Data were sourced from genome-wide association studies (GWAS) for these inflammatory markers. Causal estimates were determined using MR Egger, weighted median, and inverse variance weighting (IVW) methods. Sensitivity analyses, encompassing heterogeneity and pleiotropy tests, were also conducted. Results: Significant correlations were identified between physical activity and the inflammatory factors. For SCGF-beta, MR-Egger (P = 1.22 × 10−6, Beta = 0.5201), weighted median (Beta = 37.1429), and IVW (Beta = 103.9579) all indicated associations. For IP-10, MR-Egger (P = 0.387298409, Beta = 15.79010798), weighted median (Beta = 0.0415), and IVW (Beta = 0.3287) showed similar outcomes. For IFN-lambda 2, MR-Egger (P = 0.0018, Beta = 0.7464), weighted median (Beta = 1.0033), and IVW (Beta = 0.4616) highlighted significant associations. Conclusion: This MR study suggests that physical activity may causally influence JIA by modulating inflammatory factors such as SCGF-beta, IP-10, and IFN-lambda 2. These findings point to physical activity as a potential intervention for JIA. Further research is needed to confirm these results and explore the underlying mechanisms. (1) This study identifies a significant impact of physical activity on the risk of juvenile idiopathic arthritis by modulating inflammatory cytokines, including SCGF-beta, IP-10, and IFN-lambda 2. (2) Through Mendelian randomisation analysis, this research underscores the potential of physical activity as a non-pharmacological intervention for reducing the risk of chronic inflammatory diseases.
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